Sintesi Proteica Corporea e l'M Tor / EAA e Leucina

La Sintesi Proteica Corporea e l'M Tor che la caratterizza e' STIMOLATA sia da Stimoli Alimentari / Nutrizione Cellulare (EAAs Essential Aminoacids,Aminoacidi Essenziali,Leucina) che da Stimoli Meccanici (Allenamento Resistance Training,Allenamento contro Resistenze,Carichi almeno del 85% 1RM)

Porzioni consigliate :

3gr Leucina post Pasti (post Pranzo / post Cena e Post Allenamento) EAA Aminocidi Essenziali : Posologia Soggettiva Internation Journal of Endocrinology & Metabolism InterJ Physiol 590.11 (2012) pp 2751–2765 2751The Journal of Physiology Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistanceexercise in men Tyler A. Churchward-Venne,Nicholas A.Burd,Cameron J.Mitchell,Daniel W. D. West,Andrew Philp,George R. Marcotte,Steven K.Baker,Keith Baar and Stuart M. Phillips Exercise Metabolism Research Group,Departments of Kinesiology and Neurology, McMaster University, Hamilton, Ontario, Canada

Functional Molecular Biology Lab, Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA, USA

Tipton KD, Elliott TA, Ferrando AA, Aarsland AA & Wolfe RR (2009). Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein. Appl Physiol Nutr Metab 34, 151–161

West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T & Phillips SM (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr 94, 795–803 Atherton PJ, Smith K, Etheridge T, Rankin D & Rennie MJ(2010b). Distinct anabolic signalling responses to aminoacids in C2C12 skeletal muscle cells. Amino Acids 38,1533–1539. Borsheim E, Tipton KD, Wolf SE & Wolfe RR (2002). Essential amino acids and muscle protein recovery from resistance exercise. Am J Physiol Endocrinol Metab 283, E648– 657 Burd NA, West DW, Rerecich T, Prior T, Baker SK & PhillipsSM (2011). Validation of a single biopsy approach and bolusprotein feeding to determine myofibrillar protein synthesisin stable isotope tracer studies in humans. Nutr Metab(Lond) 8, 15 Buse MG & Reid SS (1975). Leucine. A possible regulator of protein turnover in muscle. J Clin Invest 56, 1250– 1261. Drummond MJ, Fry CS, Glynn EL, Dreyer HC, Dhanani S, Timmerman KL, Volpi E & Rasmussen BB (2009). Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol 587, 1535–1546.

Leucine and Protein Synthesis: mTor and beyond

Martha H. Stipanuk,PhDNutrition Reviews, Volume 65, Issue 3, 1 March 2007, Pages 122–129 J Nutr. 2001 Mar;131(3):861S-865S.

Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies.

Lynch CJ.

Tipton KD, Ferrando AA, Phillips SM, Doyle D Jr & Wolfe RR(1999a). Postexercise net protein synthesis in human musclefrom orally administered amino acids. Am J PhysiolEndocrinol Metab 276, E628–634.